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. 2024 Oct 13;14(10):1294. doi: 10.3390/biom14101294

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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6M 5xFAD brains exhibited decreased averaged mean kurtosis (MK) in all regions of interest (ROIs). While the differences in MK between genotypes of 2-month-old (2M) brains varied between ROIs, a small but consistent decrease was observed in the 6-month-old (6M) 5xFAD brains compared to WT brains. This difference was not statistically significant. An age-related increase was observed in the ROIs of both genotypes, although less pronounced in 5xFAD brains. This age difference was not statistically different either. Group means with 95% confidence intervals are superimposed on the individual observations. Sub = subiculum, CA = cornu ammonis of the hippocampal formation, hip = hippocampus, CC = corpus callosum, WM = white matter, LC = lower cortex, UC = upper cortex, and neo = neocortex.