Figure 8.

The relative volume of all ROIs was unchanged in 5xFAD brains. No difference was observed in the relative volume of the ROIs between genotypes. A statistically significant age × ROI interaction was observed. However, the simple main effects analysis found no statistically significant effect of age in any of the ROIs. The dotted line indicates that LC, UC, and neo are plotted against the right y-axis. Group means with 95% confidence intervals are superimposed on the individual observations. 2M = 2-month-old, 6M = 6-month-old. Sub = subiculum, CA = cornu ammonis of the hippocampal formation, hip = hippocampus, CC = corpus callosum, WM = white matter, LC = lower cortex, UC = upper cortex, and neo = neocortex.