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. 2024 Oct 1;46(10):11057–11074. doi: 10.3390/cimb46100657

Figure 4.

Figure 4

Multiple sequences of the full-length amino acid sequence of A. thaliana AtGalDH (At3g47930), with several aldonolactone oxidoreductases. The accession numbers (NCBI Entrez Protein Database) used for the multiple sequence alignment are Brassica oleracea BOGalDH (CAB09796), Nicotiana tabacum NtGalDH (BAA80870), Rattus norvegicus RnGULO (P10867), Penicillium griseoroseum gluconolactone oxidase PgGLO (AAT80870), and Saccharomyces cerevisiae ScALO (P54783). Alignment was performed using CLUSTAL X2. Amino acid residue numbers are shown on the right. Identical residues are shaded in black; similar residues are shaded in gray. The arrow marks the histidine residue involved in covalent binding of the FAD cofactor in GUO, ALO, and GLO, or the leucine residue in GalDH proteins. The FAD-binding domain in both the N-terminal and C-terminal parts is underlined. The asterisks mark the HWAK motif in RnGULO, ScALO, and all GalDH proteins.