Table 4.
TLSs in microorganism-related cancer.
| Microorganism | Tumor Type | TLSs and Prognosis | Classification of TLSs and Prognostic Value | Microorganisms and Prognosis | TLSs and Microorganisms | Ref. |
|---|---|---|---|---|---|---|
| MCPyV | MCC | Favorable | Presence | Favorable | NC | [37] |
| EBV | Gastric cancer | Favorable | Presence | NC | NM | [24] |
| EBV | NPC | Favorable | Composition (PD-1+ CXCR5− CD4+Th cells) | NM | NM | [60] |
| EBV | GOA | NM | NM | NM | NM | [90] |
| HPV | CESC | Favorable | Presence | NM | PC | [91] |
| HPV | HNSCC | Favorable | Presence; Differentiation; Composition (B cell) |
NM | PC | [12] |
| HPV | HNSCC | Favorable | Composition (CD4+ TFH) | Favorable | NM | [72] |
| HBV/HCV | HCC | Favorable | Composition (CD4+ TCM; CD20+ B cells) | NM | PC | [92] |
| HBV | ICC | Favorable | Presence; Location (intratumoral) |
Favorable | NM | [93] |
| H. hep | CRC | NM | NM | NM | PC | [94] |
| E. coli | MIBC | Favorable | Composition (CD4+ TFH) | Favorable | NM | [95] |
MCPyV, Merkel cell polyomavirus; EBV, Epstein-barr virus; HPV, human papilloma virus; HBV, hepatitis B virus; HCV, hepatitis C virus; H. hep, Helicobacter hepaticus; E. coli, Escherichia coli; MCC, Merkel cell carcinoma; NPC, nasopharyngeal carcinoma; GOA, gastroesophageal adenocarcinoma; CESC, cervical squamous-cell carcinoma; HNSCC, head and neck squamous-cell carcinoma; HCC, hepatocellular carcinoma; ICC, intrahepatic cholangiocarcinoma; CRC, colorectal cancer; MIBC, muscle-invasive bladder cancer; PD1, programmed cell death protein 1; CXCR5, C-X-C chemokine receptor type 5; Th, T follicular helper; TFH, follicular helper T; TCM, central memory T; NM, not mentioned; NC, no correlation; PC, positive correlation; Ref., Reference.