Figure 1.

Experimental timeline. After acclimatization, rats were injected intraperitoneally with DOX (6 mg/kg) or the vehicle. Beginning the day after injection, rats received either CBD (10 mg/kg in MCT oil; 4 consecutive days each week; oral route) or MCT oil alone (0.5 mL/kg) for 4 consecutive weeks. Behavioral tests were conducted serially over 4 weeks (in the order shown from top to bottom), beginning one week after experimental treatments concluded. At the end of the study, rats were euthanized, and brain tissue samples were collected for qPCR assay at week 10. DOX—doxorubicin; CBD—Cannabidiol; MCT—Medium-Chain Triglyceride; IP—intraperitoneal; EPM—Elevated Plus Maze; OFT—Open Field Test; NOR—Novel Object Recognition; MBT—Marble Burying Test; SPT—Sucrose Preference Test.