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. 2024 Sep 30;14(10):999. doi: 10.3390/brainsci14100999

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CBD suppressed neuroinflammatory response in the hippocampus of DOX-injected rats. Quantification of gene expression by qPCR. Relative mRNA expressions of Tnf (a), Nfkb1 (b), Il1b (c), Il6 (d), Tgfb1 (e), Il10 (f), GFAP (g), Aif1 (h) were measured. Real-time PCR results were standardized against Actb, and data are presented as mean ± SEM. n = 4/group; *, **, ***, ****: significant differences observed for p ≤ 0.05, p ≤ 0.01, p ≤ 0.001, p ≤ 0.0001 respectively (one-way ANOVA followed by Tukey’s post hoc test). DOX—doxorubicin; CBD—Cannabidiol; qPCR—real-time polymerase chain reaction; Tnf—tumor necrosis factor; Nfkb1—Nuclear factor kappa-light-chain-enhancer of activated B cells Subunit 1; Il1b—Interleukin beta 1; Il6—Interleukin 6; Tgfb1—Transforming growth factor beta 1; Il10—Interleukin 10; Aif1—Allograft inflammatory factor 1; Gfap—glial fibrillary acidic protein; Actb—beta actin. Some error bars may be too small to see on the chart.

CBD suppressed neuroinflammatory response in the hippocampus of DOX-injected rats. Quantification of gene expression by qPCR. Relative mRNA expressions of Tnf (a), Nfkb1 (b), Il1b (c), Il6 (d), Tgfb1 (e), Il10 (f), GFAP (g), Aif1 (h) were measured. Real-time PCR results were standardized against Actb, and data are presented as mean ± SEM. n = 4/group; *, **, ***, ****: significant differences observed for p ≤ 0.05, p ≤ 0.01, p ≤ 0.001, p ≤ 0.0001 respectively (one-way ANOVA followed by Tukey’s post hoc test). DOX—doxorubicin; CBD—Cannabidiol; qPCR—real-time polymerase chain reaction; Tnf—tumor necrosis factor; Nfkb1—Nuclear factor kappa-light-chain-enhancer of activated B cells Subunit 1; Il1b—Interleukin beta 1; Il6—Interleukin 6; Tgfb1—Transforming growth factor beta 1; Il10—Interleukin 10; Aif1—Allograft inflammatory factor 1; Gfap—glial fibrillary acidic protein; Actb—beta actin. Some error bars may be too small to see on the chart.