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. 2024 Oct 14;13(20):1700. doi: 10.3390/cells13201700

Figure 5.

Figure 5

PLK1 inhibition decreases metastatic potential and EMT in colorectal cancer cells. (A) Overexpression of PLK1 enhances the invasive ability of CRC cells. CRC cells carrying either an empty vector or PLK1 cDNA were subjected to invasion assay (n = 3). (B) Overexpression of PLK1 increases the migratory capacity of CRC cells. CRC cells carrying either an empty vector or PLK1 cDNA were subjected to migration assay (n = 3). (C) Overexpression of PLK1 triggers EMT progression. The proteins isolated from the PLK1 overexpressing CRC clones were immuno-blotted with indicated antibodies (n = 3). (D) Silencing of PLK1 decreases invasion (n = 3). PLK1 stable knockdown CRC cells were subjected to invasion assay (n = 3). (E) Silencing of PLK1 decreases migration (n = 3). PLK1 stable knockdown CRC cells were subjected to migration assay (n = 3). (F) The silencing of PLK1 leads to a reduction in the expression of EMT markers in CRC cells. The proteins isolated from the PLK1 stable knockdown CRC clones were immuno-blotted with indicated antibodies. * statistically significant in comparison to the control group, with p < 0.05.