Table 1.
Neuroprotective functions of NMPs in epilepsy models.
| Model | NMPs | Effect | Reference |
|---|---|---|---|
| Pilocarpine–epilepticus rat | CBD | Convulsant ↓ Neurodegenration ↓ |
[49] |
| PTZ seizures | CBD and CBG | Nav current in cells ↓ | [104] |
| Epilepsy-spontaneous LFPs in cells | CBDV | Amplitude and duration of LFPs ↓ Mg2+ free induced LFPs frequency ↑ |
[93] |
| Epilepsy in transfected cells (TRPV1, TRPV2, and TRPA1) | CBDV + CBD | Convulsant ↓ Phosphorylation of TRPV1 at the S800 site ↑ |
[108] |
| Electrophysiology (epileptiform bursting) (in vitro) | Δ9-THCV | Epileptiform burst ↓ | [81] |
| PTZ seizures | CBDV | Seizure severity ↓ Latency to first signs of seizure ↑ |
[93,97,98] |
| PTZ seizures | Δ9-THCV | Median seizure severity, duration, progression, or latency was unaffected | [81] |
| 6-hydroxytryptamine or LPS in rats and mice | Δ9-THCV | Neuronal loss, microglial activation, ↓ TH positive neurons and Motor activity↑ |
[109] |
| Rat model | CBD | Convulsant ↓ Seizure severity ↓ |
[61] |
| Rat (GEPR-3) strain | CBD | Seizure ↓ | [67] |
CBD, Cannabidiol; CBDV, Cannabidivarin; CBG, Cannabigerol; ∆9-THCV, ∆9-tetrahydrocannabivarin; LFS, local field potentials; PTZ, pentylenetetrazole; LPS, lipopolysaccharide; TRPV, transient receptor potential vanilloid; TH, Tyrosine hydroxylase; GEPR-3, genetically epilepsy-prone rat; ↓, reduced; ↑, enhanced.