Table 5.
Neuroprotective functions of NMPs in different SUD models.
| Model | NMPs | Effect | Reference |
|---|---|---|---|
| Humans | CBD (+THC) | Anxiety ↓ | [199] |
| Humans | CBD (+THC) | Satiety ↑ | [200] |
| Humans | CBD | Emotion, reward processing, And effects of THC ↓ |
[202] |
| Human | CBD | Withdrawal, anxiety, and dissociative symptoms ↓ | [204] |
| Human | CBD | Anxiety and cannabis use ↓ Sleep ↑ |
[205] |
| Humans | CBD | Cannabis use ↓ | [206] |
| Humans | CBD | Psychological symptoms ↓ Cognition ↑ | [207] |
| Human | CBD | Functional connectivity ↑ | [208] |
| Wistar rats | CBD | Morphine-reward behavior ↓ | [209] |
| Rat | CBD | Heroin-seeking behavior, CB1R expression ↓ | [210] |
| Mice | CBD | Anxiety, Cnr1, and Pomc ↓ Motor activity and TH expression, ↑ |
[211] |
| Mice | CBD | Gastrointestinal symptoms and jumping behavior ↓ | [212] |
| Mice | CBD | Mechanical sensitivity and jumping behavior ↓ | [213] |
| Rats | CBD | Locomotor hyperactivity and MOR ↓ Recognition memory and CB1R expression ↑ |
[214] |
| Mice | CBG | Mechanical sensitivity, Aif1, Ccl2, Calca, and Tlr4 ↓ | [215] |
CBD, Cannabidiol; THC, Tetrahydrocannabinol; CBG, Cannabigerol; TH, tyrosine hydroxylase; Pomc, Proopiomelanocortin; Cnr1, Cannabinoid receptor; MOR Mu-opioid receptor; Aif1, Allograft Inflammatory Factor 1; Ccl2, C-C Motif Chemokine Ligand 2; Calca, Calcitonin Related Polypeptide Alpha; Tlr4, Toll-Like Receptor 4; ↓, reduced; ↑, enhanced.