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. 2024 Oct 25;10(43):eadq0101. doi: 10.1126/sciadv.adq0101

Fig. 8. Therapeutic synergy of TgMIF with TB drugs against drug-resistant TB strains.

Fig. 8.

(A) Effect of the combination of TgMIF with INH (0.05, 0.1, and 0.5 μg/ml), PZA (5, 10, and 20 μg/ml), and RFP (0.025, 0.1, and 0.5 μg/ml) on MTB growth inhibition in human MDMs. Low (red circle), medium (green circle), and high (yellow circle) concentration of drugs. MOI, multiplicity of infection. (B) Inhibition of MTB growth in the lungs of MTB-infected mice by the combination of INH (15 mg/kg) and TgMIF (10 μg) (n = 35). p.o., per os. (C and D) Reduction in bacterial colony counts by TgMIF in drug-resistant TB strains. (E and F) Restoration of mitochondrial function in lungs infected with MDR-TB following TgMIF treatment. (G) Regulation of macrophage polarization markers by TgMIF in MDR-infected lungs. (H) Induction of inflammatory cytokine production by TgMIF in MTB-infected macrophages. Statistical significance was determined by the Student’s t test with Bonferroni adjustment (**P < 0.01; ***P < 0.001).