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. 2024 Oct 25;10(43):eadp2229. doi: 10.1126/sciadv.adp2229

Fig. 3. Enhancing p53 acetylation differentially affects target gene expression.

Fig. 3.

(A) qPCR analysis of the mRNA levels of the indicated genes at 8 hours after irradiation treated with or without HDACi, normalized to mRNA levels in unirradiated cells. Error bars represent SD from three biological replicates. *P < 0.05, **P < 0.01 by t test. (B) Schematic of p53 constructs harboring single or double K➔R mutations. (C) qPCR analysis of mRNA levels of CDKN1A, PAI1, PML, and PUMA after the second p53 pulse in cells expressing the indicated p53 variants and treated with or without HDACi. Error bars represent SD from three biological replicates. *P < 0.05, **P < 0.01 by t test (all conditions compared to WT + HDACi).