FIG. 5.

Quantitation of lesions per section of liver from MHV A59-inoculated mice. +/+, +/p, and p/p mice were inoculated intranasally with 10⁴, 10⁶, or 10⁸ PFU of virus per mouse, and livers were harvested at 3, 5, or 7 days postinoculation. Several experiments are illustrated. The number of lesions per section of mouse liver is shown on the y axis. Each bar indicates the number of lesions per liver section harvested from one mouse at the time indicated on the x axis. The following were not done: +/+ mice inoculated with 10⁴ PFU at day 7 and 10⁸ PFU; and +/p mice inoculated with 10⁴ and 10⁸ PFU at day 7. +/+ animals inoculated with 10⁶ PFU died or were euthanatized by day 3 or 4, whereas +/p and p/p mice survived. p/p mice were highly resistant to disease, even at doses of 10⁸ PFU/mouse. Plus signs over the bars indicate livers that had more than 50 lesions. Asterisks on the x axis indicate no liver lesions.