Table 2.

Neurosteroids or gonadal hormones that have been used as possible treatments in retinal diseases. All these hormones have been used in experimental models of retinal pathologies.

Hormone	Retinal Disease and Disease Model	Observed Effect
Estradiol	Rat model of glaucoma	Prevented RGCs death
Progesterone	Retinal explants from induced type 1 diabetic rats	Reduced osmotic swelling of retinal glial cells which promote cell survival
Progesterone	Retinitis pigmentosa: rd1 mice	Preserves the number of photoreceptors; reduces gliosis; decreases glutamate, and increases GSH,
Progesterone	Retinitis pigmentosa: rd10 mice	Increases photoreceptor survival, decreases macrogliosis
Norgestrel	Light-induced degeneration and rd10 mice	Decreases in photoreceptor apoptosis and improves the electroretinogram
Estradiol	Light-induced retinal degeneration mice model	Reduces photoreceptors death