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Post-synthetic methods for the synthesis of POCs. (a) Amide coupling reaction. (b) Disulfide activation reaction with thiol. (c) S-sulfonate-protected cysteine reaction with thiol. (d) Thiol–maleimido reaction. (e) Thiol–bromoacetamido reaction. (f) Azide––alkyne click reaction. (g) Oxime reaction. (h) Thiazolidine reaction. (i) Hydrazone reaction. (j) Diene–maleimido Diels–Alder reaction. Adapted from [6,8].
