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Acetylation of histone H4 is reduced in VP22-expressing cells. Similar amounts of acid-extracted proteins from VP22-transfected or nontransfected cells were analyzed by immunoblotting and probed with anti-acetyl-histone H4 (Lys 5) (A) and with antihistone H4 (B). Note that the acetylation of histone H4 was decreased in VP22-expressing cells compared to that of control cells.
