Figure 4.

Association between selected prebiologic characteristics and (A) three-domain and (B) four-domain asthma remission in patients with severe asthma. Three-domain remission: 0 exacerbations/yr + no long-term oral corticosteroids (LTOCS) + well- or partly controlled asthma. Four-domain remission: 0 exacerbations/yr + no LTOCS + well- or partly controlled asthma + percent predicted FEV₁ (ppFEV₁) ⩾ 80%. Gray zones highlight association patterns. *Prebiologic lung function adjustment removed. Asthma duration: age at biologic initiation minus reported age at asthma onset. All odds ratios (ORs) were adjusted for prebiologic asthma-related outcome, including in the considered remission definition, as well as for age and sex. BEC = blood eosinophil count; BMI = body mass index; CI = confidence interval; GINA = Global Initiative for Asthma; LTRA = leukotriene receptor antagonist.