Table A1.
Summary of hub genes and their protein functions from the GeneCards database.
| Gene | Protein | Function | Modules |
|---|---|---|---|
| PLK1 | Polo Like Kinase 1 | Because its depletion in cancer cells significantly reduced cell growth and caused apoptosis, cancer therapy targets this protein. | Red/Yellow/Cyan |
| EGFR | Epidermal Growth Factor Receptor | Lung cancer is linked to mutations in this gene. | Royal Blue/Purple/White/Dark Turquoise |
| ESR1 | Estrogen Receptor 1 | This gene encodes a receptor that is important in osteoporosis, endometrial cancer, and breast cancer. | Royal Blue |
| CD4 | CD4 Molecule | The protein stimulates or starts the early stage of T-cell activation and may be a key player in immune-mediated and viral disorders of the central nervous system that cause indirect neuronal damage. | Turquoise |
| CTNNB1 | Catenin β 1 | Colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer are all brought on by mutations in this gene. | Royal Blue/Dark Turquoise |
| CREBBP | CREB Binding Protein | This gene was first identified as a nuclear protein that binds to cAMP-response element-binding protein (CREB). Through the connection of chromatin remodeling to transcription factor recognition, it is now recognized to play important roles in embryonic development, growth control, and homeostasis. | Royal Blue/Dark Turquoise |
| BRD4 | Bromodomain Containing 4 | The chromosome 19 target of translocation t(15; 19)(q13; p13.1), which characterizes upper respiratory tract cancer in adolescents, has been linked to this gene. | Purple |
| CDK1 | Cyclin Dependent Kinase 1 | This protein’s phosphorylation and dephosphorylation play significant regulatory functions in the regulation of the cell cycle. | Red/Yellow/Cyan |
| CDC20 | Cell Division Cycle 20 | It appears that at various stages of the cell cycle, CDC20 functions as a regulatory protein through interactions with many other proteins. | Red/Yellow/Cyan |
| RPS11 | Ribosomal Protein S11 | This gene is distributed throughout the genome in several processed pseudogenes, as is common for genes encoding ribosomal proteins. | Royal Blue |
| CCNA2 | Cyclin A2 | This gene codes for a protein that is a member of the highly conserved cyclin family, which controls the cell cycle; adenocarcinoma and retinoblastoma are two diseases linked to CCNA2. | Yellow/Cyan |
| STAT1 | Signal Transducer and Activator of Transcription 1 | Receptor-associated kinases phosphorylate members of the STAT family in response to cytokines and growth factors. These members subsequently form homo- or heterodimers and translocate to the cell nucleus, where they function as transcription activators. | Dark Turquoise |
| SRSF1 | Serine And Arginine Rich Splicing Factor 1 | Depending on its contact partners and degree of phosphorylation, the encoded protein can either activate or suppress splicing. | White |
| BRCA1 | BRCA1 DNA Repair Associated | Hereditary breast and ovarian cancers are now identified by the presence of germline BRCA1 mutations. | Red |
| TLR4 | Toll Like Receptor 4 | The Toll-like receptor (TLR) family of proteins, which includes the protein produced by this gene, is essential for pathogen identification and the induction of innate immunity. | Turquoise |
| ITGB2 | Integrin Subunit β 2 | Integrins are essential proteins found on the cell surface that are involved in both cell adhesion and signaling mediated by the cell surface. | Turquoise |
| PTPRC | Protein Tyrosine Phosphatase Receptor Type C | Cell growth, differentiation, mitosis, and oncogenic transformation are just a few of the biological processes that PTPs are known to influence as signaling molecules. | Turquoise |
| RPS27A | Ribosomal Protein S27a | It is produced from a precursor protein that is either a single ubiquitin coupled to an unrelated protein or a polyubiquitin chain. | Royal Blue |
| HSP90AA1 | cluHeat Shock Protein 90 α Family Class A Member 1 | This gene codes for an inducible molecular chaperone protein, which is a homodimer. | Purple/White |