Table A2.

Top KEGG pathways from highly preserved modules (z > 10).

Module	KEGG Term	Count	p-Value
Yellow	Metabolic pathways	242	2.03 × 10−11
	Pathways of neurodegeneration—multiple diseases	78	1.14 × 10−4
	Alzheimer disease	72	2.45 × 10−6
	Amyotrophic lateral sclerosis	66	2.18 × 10−5
	Cell cycle	59	9.41 × 10−19
White	Pathways in cancer	65	0.039962252
	Huntington disease	41	0.038434334
	Endocytosis	39	0.003801247
	Hepatocellular carcinoma	32	3.90 × 10−4
	Tight junction	32	3.90 × 10−4
Purple	Metabolic pathways	188	1.91 × 10−5
	Herpes simplex virus 1 infection	84	2.43 × 10−7
	Chemical carcinogenesis—reactive oxygen species	31	0.0235166
	Biosynthesis of cofactors	29	2.67 × 10−4
	Peroxisome	25	2.02 × 10−7
Turquoise	Pathways in cancer	85	2.89 × 10−6
	PI3K-Akt signaling pathway	63	4.31 × 10−6
	MAPK signaling pathway	52	3.76 × 10−5
	Rap1 signaling pathway	45	6.60 × 10−7
	Regulation of actin cytoskeleton	44	1.50 × 10−5
Royal Blue	Endocytosis	33	0.047955
	Cytoskeleton in muscle cells	31	0.044336
	Hepatocellular carcinoma	24	0.04709
	mTOR signaling pathway	23	0.03917
	Nucleocytoplasmic transport	22	1.84 × 10−5
Red	Metabolic pathways	202	2.29 × 10−6
	Pathways of neurodegeneration—multiple diseases	62	0.015828
	Cell cycle	58	6.81 × 10−20
	Alzheimer disease	54	0.006263
	Amyotrophic lateral sclerosis	51	0.008789
Cyan	Metabolic pathways	240	4.52 × 10−9
	Pathways of neurodegeneration—multiple diseases	84	1.69 × 10−5
	Alzheimer disease	77	3.46 × 10−7
	Amyotrophic lateral sclerosis	70	6.20 × 10−6
	Cell cycle	65	2.89 × 10−22
Dark Turquoise	Pathways in cancer	80	3.49 × 10−4
	MAPK signaling pathway	47	0.003029
	Shigellosis	40	0.004202
	Focal adhesion	39	1.49 × 10−4
	Cytoskeleton in muscle cells	39	0.002129