TABLE 2.

Statistical analysis using the Spearman test: pairing cytokines, MT1-MMP, or TIMPs and the viral transcript (NP-CDV)^a

Variable paired with NP-CDV	Result forb:
	CX	MES	HIP	HYP	BS	CB	SC
IL-6	0.829	0.729	0.943	0.500	0.314	0.257	0.543
TNF-α	0.829	0.943	0.943	0.771	0.600	0.886	0.886
IFN-γ	1	1	0.943	0.771	0.943	1	1
IL-10	0.829	0.943	0.771	0.829	1	1	0.729
IL-4	0.914	0.771	1	0.729	0.371	0.771	1
MT1-MMP	0.943	0.600	0.714	0.714	0.143	0.543	0.829
TIMP-1	0.943	0.829	0.943	0.714	0.671	0.600	0.829
TIMP-3	0.886	0.657	0.714	0.200	−0.429	0.314	0.657

^aCorrelation analysis was performed by pairing each variable with another, using the Spearman correlation coefficient (Rho), based on the ranks of the values. Significant correlations (P < 0.05) are indicated by boldface numbers. Relationships between NP-CDV expression and that of pro- and anti-inflammatory cytokines, MT1-MMP, TIMP-1, and TIMP-3 are shown. The analyses indicate a strong correlation between the expression of cytokines and the viral transcript in a wide range of structures and a poor correlation between the expression of MT1-MMP and TIMPs and the viral transcript. 

^bCX, cortex; MES, mesencephalon; HIP, hippocampus; HYP, hypothalamus; BS, brain stem; CB, cerebellum; SC, spinal cord.