TABLE 3.

Statistical analysis using the Spearman test: pairing pro- or anti-inflammatory cytokines and MMPs or TIMPs^a

Cytokine and variable	Result forb:
	CX	MES	HIP	HYP	BS	CB	SC
MT1-MMP
IL-6	0.943	0.843	0.829	0.786	0.943	0.886	0.600
TNF-α	0.943	0.600	0.600	0.943	0.315	0.600	0.600
IFN-γ	0.943	0.600	0.657	0.943	0.257	0.543	0.829
IL-4	0.857	0.714	0.714	0.986	0.543	0.429	0.829
IL-10	0.771	0.371	0.257	0.886	0.143	0.543	0.329
TIMP-1	1	0.829	0.829	0.943	0.557	0.771	1
TIMP-1
IL-6	0.943	0.929	1	0.929	0.614	0.714	0.600
TNF-α	0.943	0.886	0.829	0.886	0.443	0.543	0.600
IFN-γ	0.943	0.829	0.886	0.943	0.757	0.600	0.829
IL-4	0.857	0.714	0.943	0.900	0.671	0.286	0.829
TIMP-3	0.886	0.771	0.829	0.143	−0.271	0.600	0.771
TIMP-3
IL-6	0.714	0.900	0.829	0.157	−0.143	0.086	0.200
IFN-γ	0.886	0.657	0.657	0.429	−0.143	0.314	0.657

^aCorrelation analysis was performed by pairing each variable with another, using the Spearman correlation coefficient (Rho), based on the ranks of the values. Significant correlations (P < 0.05) are indicated by boldface numbers. Relationship between proinflammatory and anti-inflammatory cytokines and MT1-MMP, TIMP-1, or TIMP-3 is shown. The analyses indicate a correlation between the expression of proinflammatory cytokines and MT1-MMP and TIMP-1 in a wide range of structures and between the expression of anti-inflammatory cytokines and MT1-MMP and TIMP-1 in a restricted range of structures. The expression of TIMP-3 correlated only with that of proinflammatory cytokines in a restricted range of structures. 

^bCX, cortex; MES, mesencephalon; HIP, hippocampus; HYP, hypothalamus; BS, brain stem; CB, cerebellum; SC, spinal cord.