Table 1.

EC50 values (µM ± SD) to ketoconazole, posaconazole and DB766.

Inhibitor	WT	22A1 +/−	22A1+/− +pXNG4-22A1	22A1−/− +pXNG4-22A1
Ketoconazole	2.0 ± 0.055	1.0 ± 0.074 **	2.1 ± 0.14	2.0 ± 0.19
Posaconazole	1.0 ± 0.096	0.74 ± 0.18	3.0 ± 1.0 *	1.7 ± 0.38 *
DB766	1.9 ± 0.31	2.04 ± 0.41	3.8 ± 0.68 **	3.5 ± 0.19 **

Student’s t test was performed to analyze the difference between WT and 22A1 mutant cells (*: p < 0.05; **: p < 0.01).