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[Preprint]. 2024 Oct 18:2023.10.24.563757. [Version 5] doi: 10.1101/2023.10.24.563757

Figure 5: Enantiomeric Lipid Diets Negatively Affect Cell Growth and Membrane Properties.

Figure 5:

a Enantiomeric (Ent) POPC is a synthetic chiral POPC with the head group in the SN1 position, rather than SN3 position. b M. mycoides and c JCVI-Syn3A cells exhibit slower growth when grown on diets with enantiomeric POPC present; are more fragile to hypoosmotic shock when grown on diets with enantiomeric POPC present; and are more permeable to non-chiral fluorescein diacetate (FDA) when grown on diets with enantiomeric POPC present. d M. mycoides and e JCVI-Syn3A cell growth and membrane permeability are inversely correlated. Error bars are mean +/− SD. * equals p-value < 0.1; ** equals p-value < 0.05; *** equals p-value < 0.01. N, number of replicates, for all growth rates was 5 or greater and can be found in Supplementary Table S2. N=3 for osmotic sensitivity and permeability subfigures.