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[Preprint]. 2024 Oct 17:2024.10.14.618289. [Version 1] doi: 10.1101/2024.10.14.618289

Fig. 9. Microglia activation-associated hypertrophy and proliferation due to the R345W mutation is prevented in Nlrp3 deficient mice.

Fig. 9.

Nlrp3−/− R345W+/+ mice. (22 mo) mice compared to R345W+/+ (20 mo). Representative images (n = 4–6) of Iba1+ (green) stained microglia in the ganglion cell layer (GCL), inner plexiform layer (IPL), outer plexiform layer (OPL), photoreceptor layer (PR) and RPE (scale bar = 100 μm). Graphs representing cell densities in each of the specified layers showing significant reductions in microglia densities in the GCL, IPL, PR, and RPE layers. Note: data presented here were analyzed using a two-way ANOVA in combination with data presented in Fig. 6. **** p < 0.0001. Mean ± S.D. Note: R345W+/+ images and quantification are identical to that shown earlier in Fig. 6.