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[Preprint]. 2024 Oct 18:2024.10.16.618588. [Version 1] doi: 10.1101/2024.10.16.618588

Figure 2: Methylation clock accuracy is lower in cohorts with substantial African genetic ancestry.

Figure 2:

A: Pearson correlation between chronological age and DNAm age predicted by the Horvath clock for controls in the white MAGENTA cohort. The correlation of 0.72 is similar to previous studies of older cohorts. B: Pearson correlation between chronological age and DNAm age predicted by the Horvath clock for the genetically admixed cohorts in MAGENTA. The right plot in each pair shows the proportion of European (CEU), African (YRI), and American (PEL) global ancestry for each individual in each cohort. The two cohorts with substantial African ancestry—African Americans and Puerto Ricans—have significantly lower correlations than the other cohorts. C: Difference in correlation between chronological and predicted DNAm age for controls in each cohort compared to the white cohort controls for four methylation clocks. The baseline correlation for the white cohort controls is given in each panel; asterisks indicate a statistically significant difference from the baseline. * p < 0.05.