Figure 3: Methylation clocks rarely identify accelerated aging in admixed Alzheimer’s cohorts.

A: Comparison of the distributions of Horvath intrinsic age acceleration for AD patients and non-demented controls for each of the admixed cohorts in MAGENTA. AD patients do not show significantly higher age acceleration in any of the admixed cohorts. In contrast, the AD cases had significantly greater acceleration than controls in the white cohort (Supplementary Figure 1). NS = Not significant. B: Median differences in intrinsic age acceleration between AD patients and non-demented controls for five methylation clocks for each cohort in MAGENTA. The clocks do not consistently identfy accelerated aging in AD across cohorts, and the results also vary within cohorts. * p < 0.05.