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. 2005 Jun 6;102(24):8704–8709. doi: 10.1073/pnas.0408887102

Fig. 5.

Fig. 5.

Treatment of MIN-6 cells with IA-2 siRNA. (A and B) IA-2 siRNA treatment decreased glucose-induced insulin secretion (A) and insulin content (B) of IA-2F-transfected MIN-6 cells. (C) IA-2 siRNA treatment decreased the insulin content of nontransfected MIN-6 cells. Nonsilencing siRNA had no effect. (D) Treatment of nontransfected MIN-6 cells with IA-2 siRNA decreased the expression of vesicle-related proteins. IA-2 and α-tubulin expression was determined by Western blot analysis. Mean ± SEM of three separate experiments. *, P < 0.05; **, P < 0.01.