FIG. 5.

Diagram of VP5 configuration predicted from primary amino acid analysis. (A) Structural features and domains of VP5 identified using computer-assisted two-dimensional HCA analysis (6), as well as the “coils” and “learncoils” programs (3, 44). (B) Helical wheel representation of aa 1 to 19 and 22 to 41 of VP5. Each panel represents an α-helix viewed along the helix axis with the indicated amino acid residues. The VP5 sequence was searched for the presence of amphipathic structures initially using the program Moment of the GCG software package. The program Helical Wheel was then used to plot a helical wheel representation of the N-terminal amino acids of VP5 (18).