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Heart failure and CSC senescence. c-kit positive CSCs (green, A-F) express p16INK4a (yellow, A and B) and p53 (magenta, C and D). The detection of telomeres in c-kit-positive CSCs is shown by small white fluorescence dots (E and F). Shown are control myocardium (A), acute infarcts (C and E), and chronic infarcts (B, D, and F). (Scale bars: 10 μm.)
