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. 2024 Oct 18;25(20):11198. doi: 10.3390/ijms252011198

Figure 2.

Figure 2

Reactions of Thiamine and Tyrosine residues of α-synuclein with Peroxynitrite. Suggested competing effects of thiamine towards tyrosine residues of α-synuclein protein for peroxynitrite binding: reduction and blocking of the oxidant action of per-oxynitrite on tyrosine residues of α-synuclein, due to the greater affinity of peroxyni-trite (formal charge, 1−) for thiamine (formal charge, 1+) compared with tyrosine (formal charge, 0). For reactions 1 and 2, see also reference [52].