(A) Effect of EGFR inhibitor, Gefitinib, on cell viability in PC-3 cells. Outcome was evaluated by means of MTT assay. Results are expressed as percentage of control value. Data correspond to mean ± S.E.M. of at least two independent experiments in triplicate; **, p < 0.01; ***, p < 0.001 vs. control. (B) Effect of GHRH-R antagonist MIA-690 (0.1 μM) and Gefitinib (200 μM) on cell viability in PC-3 cells. Outcome was evaluated by means of MTT assay. Results are expressed as percentage of control value. Data correspond to mean ± S.E.M. of at least three independent experiments in triplicate; ***, p < 0.001 vs. control; ###, p < 0.001 vs. treatment with MIA-690 alone; +++, p < 0.001 vs. treatment with Gefitinib alone.