Table 6.

Diagnostic algorithm in healthy patients at risk of heart failure.

Screening for Heart Stress in Asymptomatic Patients with T2DM (or Other CVRFs)
NT-proBNP (pg/mL)	Age (years)	Diagnosis and management
≤50	Age-independent	Heart stress very unlikely	Repeat NT-proBNP in one year
51–74	<50	Heart stress not likely (Grey zone)	Repeat NT-proBNP in six months
51–149	50–74
51–299	≥74
≥75	<50	Heart stress likely	Arrange echocardiography Assessment by heart failure team if cardiac dysfunction present Reassess NT-proBNP every 6–12 months
≥150	50–74
≥300	≥74

T2DM, type 2 diabetes mellitus; CVRFs, cardiovascular risk factors; NT-proBNP, N-terminal pro-B-type natriuretic peptide; HF, heart failure.