Table 1.
Association between CD11b, CD8, CD163, and clinicopathologic findings of distal bile duct cancer.
| CD11b | CD8 | CD163 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | High (n = 38) (%) |
Low (n = 52) (%) |
p-Value | High (n = 40) (%) |
Low (n = 50) (%) |
p-Value | High (n = 70) (%) |
Low (n = 20) (%) |
p-Value |
| Age (mean ± SD) | 66.7 ± 10.4 | 68.0 ± 9.6 | 0.557 * | 66.1 ± 9.4 | 68.5 ± 10.3 | 0.247 * | 66.9± 10.0 | 69.4 ± 9.5 | 0.317 * |
| Gender | 0.626 | 0.981 | 0.510 | ||||||
| Male | 24 (63.2) | 29 (55.8) | 23 (57.5) | 30 (60.0) | 43 (61.4) | 10 (50.0) | |||
| Female | 14 (36.8) | 23 (44.2) | 17 (42.5) | 20 (40.0) | 27 (38.6) | 10 (50.0) | |||
| Tumor size (mean ± SD) | 3.2± 1.5 | 3.0 ± 1.3 | 0.726 * | 3.0 ± 1.3 | 3.2 ± 1.5 | 0.549 * | 3.1 ± 1.3 | 3.1 ± 1.5 | 0.936 * |
| Histologic grade | 0.358 | 0.707 | 0.206 | ||||||
| Well | 8 (21.1) | 16 (30.8) | 9 (22.5) | 15(30.0) | 16 (22.9) | 8 (40.0) | |||
| Moderate Poorly |
23 (60.5) 7 (18.4) |
31 (59.6) 5 (9.6) |
25 (62.5) 6 (15.0) |
29(58.0) 6 (12.0) |
43 (61.4) 11 (15.7) |
11 (55.0) 1 (5.0) |
|||
| T stage | 0.318 | 0.002 | 0.372 | ||||||
| T1 | 7 (18.4) | 17 (32.7) | 15 (37.5) | 9 (18.0) | 21 (30.0) | 3 (15.0) | |||
| T2 | 14 (36.8) | 16 (30.8) | 17(42.5) | 13(26.0) | 23 (32.9) | 7 (35.0) | |||
| T3 | 17 (44.7) | 19 (36.5) | 18(20.0) | 28(56.0) | 26 (37.1) | 10 (50.0) | |||
| N stage | 0.723 | 0.338 | 0.678 | ||||||
| N0 | 24 (63.2) | 37 (71.2) | 30(75.0) | 31(62.0) | 46 (65.7) | 15 (75.0) | |||
| N1 N2 |
12 (31.6) 2 (5.3) |
13 (25.0) 2 (3.8) |
8 (20.0) 2 (5.0) |
17(34.0) 2(4.0%) |
21 (30.0) 3 (4.3) |
4 (20.0) 1 (5.0) |
|||
| Lymphovascular invasion | 1 | 0.832 | 1 | ||||||
| Yes | 19 (50.0) | 26 (50.0) | 19(47.5) | 26(52.0) | 35 (50.0) | 10 (50.0) | |||
| No | 19 (50.0) | 26 (50.0) | 21(52.5) | 24 (48.0) | 35 (50.0) | 10 (50.0) | |||
| Perineural invasion | 0.803 | 0.583 | 0.654 | ||||||
| Yes | 29 (76.3) | 42 (80.8) | 30(75.0) | 41 (82.0) | 54 (77.1) | 17 (85.0) | |||
| No | 9 (23.7) | 10 (19.2) | 10(25.0) | 9 (18.0) | 16 (22.9) | 3 (15.0) | |||
| Margin status of the bile duct | 0.386 | 0.189 | 0.560 | ||||||
| R0 | 32 (84.2) | 48 (92.3) | 38(95.0) | 42(84.0) | 61 (87.1) | 19 (95.0) | |||
| R1 | 6 (15.8) | 4 (7.7) | 2 (5.0) | 8 (16.0) | 9 (12.9) | 1 (5.0) | |||
SD, standard deviation; *, t-test; R0, clear resection margin; R1, positive resection margin on microscopic examination.