Table 3.

Univariate and multivariate analyses of factors associated with overall survival of distal bile duct cancer.

Clinicopathologic Factors	Univariate Analysis			Multivariate Analysis
	HR	95% CI	p-Value	HR	95% CI	p-Value
Age (years)	1.006	0.980–1.033	0.649
Gender
Male
Female	0.971	0.590–1.599	0.909
Tumor size	0.993	0.828–1.190	0.937
Histologic grade
Well
Moderate	1.410	0.800–2.484	0.235
Poorly	1.372	0.615–3.062	0.440
pT stage
pT1
PT2	4.967	2.061–11.974	<0.001	5.221	1.989–13.704	<0.001
PT3	9.584	4.008–22.920	<0.001	6.785	2.646–17.397	<0.001
pN stage
pN0
pN1	1.760	1.019–3.040	0.043	1.267	0.721–2.226	0.411
pN2	4.565	1.334–15.615	0.016	2.711	0.782–9.390	0.116
Lymphovascular invasion
No
Yes	1.595	0.970–2.624	0.066
Margin status of the bile duct
R0
R1	2.046	1.030–4.066	0.041	0.969	0.479–1.962	0.931
Perineural invasion
No
Yes	0.764	0.406–1.436	0.403
Low CD11b/ high CD8
No
Yes	0.124	0.050–0.311	<0.001	0.159	0.061–0.410	<0.001

R0, clear resection margin; R1, positive resection margin on microscopic examination.