Fig. 6.

Tubacin inhibits paracrine MM cell growth. MM.1S (A) and RPMI8226 (B) cells were cultured for 24 h in BMSC-coated or noncoated plates in control media (white bars) and with 1.25 (light gray bars), 2.5 (dark gray bars), or 5 μM (black bars) tubacin, in the presence or absence of bortezomib (2.5 and 5 μM). DNA synthesis was assessed by [³H]thymidine uptake; data represent mean (±SD) of quadruplicate cultures.