Table 3.
Genetic association analysis of EBF1 SNP rs2963463 across familial sPTB, sporadic sPTB, and controls, using different inheritance/genetic models.
| Cases | Controls (N = 281) |
χ2 | p | p adj * | |||
|---|---|---|---|---|---|---|---|
| Familiar sPTB (N = 44) |
Sporadic sPTB (N = 248) |
||||||
| EBF1 SNP rs2963463 T/C | |||||||
| genotype | TT | 6 (13.64) | 19 (7.79) | 17 (6.09) | 12.34 | 0.015 a | 0.300 |
| TC | 23 (52.27) | 133 (54.51) | 121 (43.37) | ||||
| CC | 15 (34.09) | 92 (37.70) | 141 (50.54) | ||||
| allele | T | 35 (39.77) | 147 (30.12) | 155 (27.78) | 10.85 | 0.210 | 1.260 |
| C | 53 (60.23) | 341 (69.88) | 403 (72.22) | ||||
Bold denotes statistical significance. * Bonferroni correction. a Familial sPTB vs. controls χ2 = 5.69, p = 0.017, p adj = 0.102; sporadic sPTB vs. controls χ2 = 7.37, p = 0.007, p adj = 0.042.