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Plot of buried accessible areas vs. Kd constants for various dimers. Blue diamonds correspond to data points taken from refs. 17 and 18, although surface areas are replotted as indicated in the text. Green triangles correspond to domain-swap dimers (33–38). The circled red square denotes the E-cadherin dimer. Note that the domain swapped dimers tend to have low affinities even when they have large buried surface areas.
