Figure 6.

Obesity modulates the expression of genes in NVU cell types associated with neurodegenerative diseases. (A) Venn diagram showing the number of significant associations between DEGs of NVU cell types and neurodegenerative diseases. (B) Network representing interactions between genes differentially expressed by obesity in the NVU cell types with Alzheimer’s disease, cerebrovascular diseases, and dementia. DEGs in endothelial cells (e, green circles), astrocytes (a, blue circles), neuronal cells (n, yellow circles), and microglial cells (m, pink circles).