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Obesity predisposes to increased blood–brain barrier permeability. (A) Representative magnetic resonance imaging (MRI) images of the brain pre- and post-gadolinium (Gd) infusion for ob/ob and WT mice and percent difference in intensity. (B) Dynamic contrast enhanced (DCE) plots showing relative signal intensity (y-axis) over time (x-axis). (C) Area under the cure (AUC) of the DCE plot for ob/ob and WT mice (n = 8–9/genotype).
