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. 2024 Oct 11;13(20):6069. doi: 10.3390/jcm13206069

Table 2.

Laboratory, biochemical data, and cryoglobulinemia characteristics of patients.

Rheumatic Diseases
(n = 47)		 Hepatotropic Viruses
(n = 91)		 Hematological Diseases
(n = 17)		 Essential CG
(n = 17)
Cryoglobulinemia Characteristics

  • Protein cryoprecipitate (mg/dL), x¯ (±SD)

  • Isotype Ig, n (%)

 26.7 (±63.2)
G + M = 26 (55.3)		 65.8 (±256.5)
G + M = 72 (79.1)		 292.4 (±546.2)
M = 8 (47.1)		 47.59 (±79.1)
G + M = 12(70.6)		 p = 0.0001
p = 0.0067
Biochemical and Immunological Features

  • CKD ≥ 3 stage, n (%)

 7 (14.9) 9 (9.9) 3 (17.6) 7 (41.2) p = 0.0170

  • B2M (≥1.8 mg/L), n (%)

 7/40 (17.5) 1/5 (20.0) 3/12 (25.0) 0 (0) p = 0.4489

  • CRP (mg/L) p50

 10.3 (±26.2) 3.9 (±3.0) 13.4 (±18.3) 8.5 (±12.0) p = 0.4749

  • ESR (mm/h) p50

 40.0 (±28.5) 20.3 (±20.2) 35.4 (±35.1) 24.5 (±25.0) p = 0.0003

  • ANA+, n (%)

 37/46 (80.4) 27/56 (48.2) 5/13 (38.5) 9/16 (56.3) p = 0.0032

  • Titers (≥1:640)

 18 (48.7) 3 (11.1) 1 (20) 2(22.2) p = 0.0116

  • RF + (>20 IU/mL), n (%)

 19/46 (41.3) 44/86 (51.2) 5/11 (45.5) 7/17 (41.2) p = 0.0945
  • -

    x¯ (±SD)

 90.6 (±175.9) 161.0 (±219.5) 94.8 (±135.6) 284.5 (±619.3) N/A

  • Low C3 (<85 mg/dL), n (%)

 20 (42.6) 47 (51.6) 3 (17.6) 3 (17.6) p = 0.1355
  • -

    x¯ (±SD)

 90.1 (±28.6) 68.5 (±10.8) 99.1 (±29.0) 114.8 (±12.7) N/A

  • Low C4 (<12 mg/dL), n (%)

 17 (36.2) 36 (39.6) 0 (0) 3 (17.6) p = 0.0252
  • -

    x¯ (±SD)

 15.6 (±9.0) 7.6 (±3.5) 20.4 (±7.4) 21.1 (±9.5) N/A

Detailed laboratory findings of the 172 patients of our cohort. Ig, immunoglobulin; CKD, chronic kidney disease; B2M, beta-2 microglobulin; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; ANA, antinuclear antibodies; RF, rheumatoid factor; C3, complement C3; C4, complement C4; N/A, not applicable.