TABLE 3.
Kinetics of the neutralizing antibody response in mice deficient in type I, type II, or both type I and II IFN receptors compared to their 129/SvEv congenic controls following infection with a high dose of LCMV-Docilea
| Mouse strain | Neutralizing antibody titer (log2, 10)b at the following time after infection (days):
|
||||
|---|---|---|---|---|---|
| 15 | 30 | 50 | 70 | 90 | |
| 129/SvEv | 1.3 ± 0.3 | 2.0 ± 0.0 | 3.5 ± 0.5 | 5.0 ± 1.0 | 5.0 ± 0.5 |
| IFN-α/βR−/− | 1.5 ± 0.5 | 1.5 ± 1.5 | 2.8 ± 0.3 | 3.0 ± 1.0 | 2.2 ± 1.2 |
| IFN-γR− | 1.0 ± 0.0 | 2.8 ± 0.3 | 1.5 ±t0.5 | 3.0 ± 0.0 | 3.0 ± 0.0 |
| IFN-α/β-γR−/− | 1.5 ± 0.5 | 1.3 ± 0.3 | 2.3 ± 0.3 | 2.5 ± 1.5 | 2.2 ± 0.8 |
a
IFN-α/βR−/−, IFN-γR−/−, IFN-α/β-γR−/−, or 129/SvEv mice were infected with 106 PFU of LCMV-Docile. Sera were analyzed for neutralizing antibody activity as described in Materials and Methods.
b
Data are means and standard errors of the means for three to five mice.