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. 2024 Oct 18;25(20):11199. doi: 10.3390/ijms252011199

Figure 1.

Figure 1

Bioenergetic readouts in iPSCs from young versus old donors. Readouts include ATP generation (ATP), mitochondrial membrane potential (MMP), mitochondrial ROS (DHR), mitochondrial superoxide anion (MitoSOX) levels, and mitochondrial mass. Data were normalized on the CellTracker blue signal, an indicator of living cell surface area, and are shown as the percentage of iPSCs derived from young donors. Values represent the mean ± SEM of 10–12 replicates/donor/readout, for four young and four aged donors, and three independent experiments (Total n = 123–150 replicates/group), and are shown as the percentage of iPSCs derived from young donors. (dashed line). Student t-test between iPSCs from young vs. aged donors *** p < 0.001.