Table 1.

Models used for the definition of the initial protein concentration ranges. R stands for the number of reactions in the given model.

Mechanism	R	Cell Type	Relevant Species	Source
Apoptosis	23	HeLa	procaspase	[15]
Apoptosis	25	HeLa	procaspase, BID, tBID	[16]
Apoptosis	24	E.coli	cyt c, BIT, Bax, procasp	[19]
Apoptosis	20	HeLa	p53, MDM2	[17]
Apoptosis	19	MCF7	PUMA, Bax, BCL2 and their complexes	[18]
Apoptosis	5	MCF7	p53, MDM2	[14]
${\mathrm{Ca}}^{2+}$ signaling /Ras	43	not specified	Ca ions, SERCA, PIP$\_2$, PLC, IP$\_3$	[38]
${\mathrm{Ca}}^{2+}$ signaling/Ras	11	eukaryotic	Ca ions, G-proteins, PLC, IP$\_3$	[39]
JNK/p38 cas	12	not specified	JNK, MAPK	[45]
Autophagy and apoptosis	13	RTP	ATG5, autophagosomes, BCL2, BEC1, Ca ions, CALPAIN, caspase, DAPK, PI3R, JNK, mTOR	[46]
mTOR signaling	25	HeLa	AKT, mTOR, TSC1/2, PI3K	[44]
mTOR signaling	18	HeLa	AKT, mTOR	[47]
EGFR signaling	129	NSCLC	PIP2, AKT	[48]
Ras signaling	6	SB2 melanoma	PKC, cAMP, G-proteins, PIP2, PKA, MAPK,	[49]
mTOR signaling	13	Human	mTOR	[50]