Table 2.

Publicly available tools for the read-across workflow. All links were accessed on 20 September 2024.

Tool	Remarks	Link	Reference
AMBIT	Used for substance identification and similarity assessment.	https://cefic-lri.org/toolbox/ambit/	[103]
QSAR Toolbox	Utilized to develop hypotheses and evaluate assessment elements by providing mechanistic and endpoint-specific data.	https://qsartoolbox.org/	[104]
ToxRead	Provides toxicity predictions and read-across justification based on structural and mechanistic similarities.	https://www.vegahub.eu/download/toxread-download/	[105]
ToxMatch	Useful for identifying substances and scenarios by finding similar compounds and creating matrices.	https://toxmatch.sourceforge.net/	[106]
GenRA	Supports hypothesis development and evaluation by offering a read-across methodology that predicts toxicity based on chemical similarity and existing data.	https://comptox.epa.gov/genra/	[107]
ToxGPS	Used for collecting evidence and evaluating assessments by combining data sources to offer detailed toxicity profiles and predictions.	https://mn-am.com/products/chemtunestoxgps/	[108]
VERA	Uses multiple similarity metrics and clusters of analogues	https://www.vegahub.eu/portfolio-item/vera/	[109]