Table 1.

Amiodarone indications as a first- or second-line therapy reported by the cited guidelines.

Indication	First-Line AADs	Second-Line AADs	Reference
Cardiac arrest VF Hemodynamically unstable VT	IV amiodarone IV lidocaine	N/A	[19]
Stable VT	IV verapamil—fascicular VT IV beta-blockers—outflow tract VT IV procainamide	IV amiodarone IV flecainide IV sotalol	[20]
AF—acute cardioversion	IV flecainide IV propafenone	IV amiodarone IV vernakalant	[21]
AF—acute rate control	IV beta-blockers (metoprolol tartrate, esmolol, landiolol) IV verapamil IV diltiazem	IV amiodarone	[21]
Other supraventricular tachyarrhythmias—acute rate control	IV adenosine	IV amiodarone	[21]
Prevention of recurrent ICD shocks and VT	PO beta-blockers PO amiodarone	AAD according to underlying disease and cardiac function	[20]
AF—prevention of recurrent AF	PO amiodarone PO dronedarone PO flecainide PO propafenone	PO sotalol	[21]
AF—rate control	PO beta-blockers (metoprolol tartrate, metoprolol succinate, bisoprolol, atenolol, nebivolol, carvedilol)	PO verapamil PO diltiazem PO digoxin. PO amiodarone only as a last line.	[21]

AADs, antiarrhythmic drugs; VF, ventricular fibrillation; VT, ventricular tachycardia; AF, atrial fibrillation; ICD, implantable cardioverter-defibrillator; IV, intravenous; PO, per os; N/A, not applicable.