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TABLE 2.

Cross-neutralization activity in serum from vaccinated monkeys

Monkey serum sourcea Monkeye PRNT80 or PRNT50d in animals infected with:
SEOV
HTNV
DOBV
PUUV
80% 50% 80% 50% 80% 50% 80% 50%
Vaccinatedb with pWRG/SEO-M(x) CH03 640 1,280 40 160
CH32 1,280 1,280 80 320 640 40
Vaccinatedb with pWRG/HTN-M(x) CH28 2,560 2,560 320
CH02 5,120 10,240 160 320
CH27 20 640 1,280 80 320
Vaccinatedc with rVV/HTN-M+S 62F 40 160 80
CH21 320 640 160
AA016 320 320 20
a

Monkey serum was collected 3 weeks after the final vaccination. 

b

Monkeys were gene gun-vaccinated three times at 3-week intervals with the indicated DNA vaccine plasmid. 

c

Monkeys were injected subcutaneously with recombinant vaccinia virus vaccine two times at a 42-day interval. 

d

PRNT values are the reciprocal serum dilutions that neutralize the indicated virus plaque number by 80% or 50%. Homologous titers are shown in boldface. ∗, Titer of <20. 

e

Monkey identification code.