Table 1.
MIC | Patient A | Patient B | CDC’s Tentative MIC Breakpoints |
||
---|---|---|---|---|---|
Amphotericin B | 2 | R | 4 | R | ≥2 |
Anidulafungin | 0.12 | S | 0.12 | S | ≥4 |
Caspofungin | 0.12 | S | 0.12 | S | ≥2 |
Fluconazole | 128 | R | 256 | R | ≥32 |
Isavuconazole | 0.06 | N/A * | 0.12 | N/A | N/A |
Itraconazole | 0.12 | N/A | 0.25 | N/A | N/A |
Micafungin | 0.12 | S | 0.12 | S | ≥4 |
Posaconazole | 0.06 | N/A | 0.06 | N/A | N/A |
Voriconazole | 0.5 | N/A | 0.5 | N/A | N/A |
Mutations | |||||
Gene | Gene ID | Substitution | |||
CIS2 | B9J08_01093 | K74E | |||
ERG4 | B9J08_00711 | M192I | |||
SNQ2 | B9J08_03375 | K52N | |||
STE6 | B9J08_05399 | K719N | |||
ERG11 | B9J08_03698 | Y132F+ | |||
TAC1B | B9J08_04780 | A583S | |||
FCY1 | PIS48695.1 | S70R+ |