Table 2.
Antimicrobial activity of representative compounds of the RALs with ketal groups 1.
| Compound | MIC90 (µM) | |||||
|---|---|---|---|---|---|---|
| M. marinum | S. aureus | E. coli | P. aeruginosa | C. albicans | V. vulnificus | |
| 11 | >200 | >100 | >100 | >100 | >100 | >100 |
| 15 | 80 | 25 | >100 | >100 | >100 | >100 |
| 16 | 80 | >100 | >100 | >100 | >100 | >100 |
| 17 | 80 | >100 | >100 | >100 | >100 | >100 |
| 18 | 70 | >100 | >100 | >100 | >100 | >100 |
| 19 | 70 | >100 | >100 | >100 | >100 | >100 |
| 20 | 70 | >100 | >100 | >100 | >100 | >100 |
| 21 | 80 | 25 | >100 | >100 | >100 | >100 |
| 22 | 80 | >100 | nt | >100 | >100 | nt |
| 23 | 80 | >100 | >100 | >100 | >100 | >100 |
| 24 | 70 | >100 | >100 | >100 | >100 | 25 |
| 28 | 70 | >100 | >100 | >100 | >100 | >100 |
| 29 | 70 | 50 | >100 | >100 | >100 | >100 |
| 30 | 80 | >100 | 25 | >100 | >100 | >100 |
| 31 | 80 | >100 | >100 | >100 | >100 | >100 |
| 32 | 80 | >100 | nt | >100 | >100 | nt |
| 33 | 80 | >100 | nt | >100 | >100 | nt |
| 34 | 90 | >100 | nt | >100 | >100 | nt |
| 35 | 80 | >100 | nt | >100 | >100 | nt |
| Isoniazid | 40 | nt | nt | nt | nt | nt |
| Rifampicin | 10 | nt | nt | nt | nt | nt |
| Ciprofloxacin | nt | 3.13 | 0.10 | 1.56 | nt | nt |
| Amphotericin B | nt | nt | nt | nt | 0.84 | nt |
| Chloramphenicol | nt | nt | nt | nt | nt | 9.75 |
1 Results are the average of three independent experiments, each performed in duplicate. Standard deviations were less than ±10%. nt = not tested.