Table 2.
Effects of compounds 1–8 on cell viability. Cells were incubated with increasing doses of each compound (up to 50 µM). Cell viability was measured after 48 h incubation by an MTS reduction assay as mentioned in the Materials and Methods. EC50 values (µM) were calculated from the dose–response curves.
| Compound | EC50 (µM) | ||
|---|---|---|---|
| RPE-1 | HCT-116 | U2OS | |
| 1 | 0.176 | 0.087 | 0.896 |
| 2 | 10.030 | 13.730 | 13.180 |
| 3 | 23.140 | 62.950 | 35.090 |
| 4 | 16.700 | 84.380 | 39.790 |
| 5 | 5.222 | 8.036 | 7.351 |
| 6 | 0.058 | 0.170 | 0.232 |
| 7 | >25 | >25 | >25 |
| 8 | >25 | >25 | >25 |
| Staurosporine | 1.900 | 25.700 | 9.900 |