Table 2.

Comparison of remimazolam-related perioperative variables between the old vs. the elderly groups.

Group	Old Group	Elderly Group	p-Value
n	52	47
Intraoperative remimazolam
Infusion rate (ug/kg/min)	23.0 ± 5.3	21.5 ± 5.5	0.2
Total infusion time (min)	101.0 ± 22.7	93.4 ± 17.5	0.054
Primary outcome
flumazenil required in the OR	13 (25.0%)	18 (38.3%)	0.154
Secondary outcomes
1. Induction of general anesthesia
Apnea occurrence	40 (76.9%)	40 (85.1%)	0.302
Time to apnea onset (s)	99.8 ± 14.0	100.2 ± 19.9	0.923
Achievement of BIS < 60	43 (82.7%)	35 (74.5%)	0.318
Time to BIS < 60 (s)	316.3 ± 486.5	358.8 ± 469.8	0.698
2. Awake variables in general anesthesia
Achievement of BIS > 80	43 (82.7%)	39 (83.0%)	0.97
Time to BIS > 80 (s)	277.7 ± 234.2	267.7 ± 214.9	0.842

Abbreviations: BIS, bispectral index; OR, operating room; Values are expressed as mean (standard deviation) and number (percentage).