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NifLA system mechanism. To activate nif gene expression, NifA cannot be interacting with NifL. This complex dissociates when NifL is reduced or when NifA is saturated by α-ketoglutarate (a-KG). When nitrogen levels in the cell are low, GlnK is uridylylated by GlnD and unable to bind NifL. When nitrogen levels are high, GlnK is de-uridylyated and binds NifL, stimulating the formation of the NifLA-GlnK complex.
